Liver & intrahepatic bile ducts

Systemic conditions


Last author update: 1 May 2012
Last staff update: 8 July 2022

Copyright: 2002-2023,, Inc.

PubMed Search: Amyloidosis liver

Komal Arora, M.D.
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Cite this page: Arora K. Amyloidosis. website. Accessed June 2nd, 2023.
Definition / general
Case reports
Gross images

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Spontaneous rupture of
liver associated with
treatment for systemic
AL amyloidosis

Microscopic (histologic) description
  • Amyloid deposition in blood vessels and sinusoids, leading to atrophic hepatocyte cell plates
  • May have pericellular fibrosis
Microscopic (histologic) images

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AL (systemic) amyloidosis

Myeloma associated amyloidosis

Portal arteriole: sulfated Alcian blue stain

Positive stains
  • Congo red (apple green birefringence with polarized microscopy)
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