Liver & intrahepatic bile ducts
Systemic conditions
Amyloidosis
Author: Komal Arora, M.D.
Last author update: 1 May 2012
Last staff update: 8 July 2022
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Amyloidosis liver
Table of Contents
Definition / general | Case reports | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stainsCite this page: Arora K. Amyloidosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/liveramyloidosis.html. Accessed June 2nd, 2023.
Definition / general
- Liver involvement in primary or secondary amyloidosis
- Usually AL type (Pathologe 2009;30:240)
Case reports
- 55 year old woman with systemic AL amyloidosis undergoing treatment with high dose melphalan and autologous stem cell transplantation who died due to spontaneous hepatic rupture (Amyloid 2009;16:103)
- Associated with primary sclerosing cholangitis (Eur J Gastroenterol Hepatol 2010;22:1265)
Gross images
Images hosted on other servers:
Spontaneous rupture of
liver associated with
treatment for systemic
AL amyloidosis
Microscopic (histologic) description
- Amyloid deposition in blood vessels and sinusoids, leading to atrophic hepatocyte cell plates
- May have pericellular fibrosis
Microscopic (histologic) images
Images hosted on other servers:
AL (systemic) amyloidosis
Myeloma associated amyloidosis
Portal arteriole: sulfated Alcian blue stain
Positive stains
- Congo red (apple green birefringence with polarized microscopy)
