Mandible & maxilla

Benign epithelial odontogenic tumors

Squamous odontogenic tumor

Topic Completed: 1 January 2004

Minor changes: 9 November 2020

Copyright: 2004-2021,, Inc.

PubMed Search: Squamous odontogenic tumor (mandible OR maxilla)

Nat Pernick, M.D.
Page views in 2020: 2,262
Page views in 2021 to date: 2,281
Cite this page: Pernick N. Squamous odontogenic tumor. website. Accessed October 28th, 2021.
Definition / general
  • Uncommon
  • Most common in 20s but occurs in all ages, 2/3 male
  • Usually in anterior maxilla or posterior mandible in soft tissue or bone; 25% are multiple lesions
  • Arises from rests of Malassez in periodontal ligament
  • Low probability of recurrence, no malignant transformation reported
Radiology description
  • Well circumscribed
  • Semicircular radiolucency
  • Sclerotic border
  • Near teeth roots
Case reports
  • Excision with extraction of involved teeth or en bloc resection
Microscopic (histologic) description
  • Anastomosing islands of benign, stratified squamous epithelium within fibrous stroma, often well defined nests with clear cells
  • May contain keratin or psammoma bodies
  • Often epithelial vacuolization and microcysts
  • No atypia, no mitotic figures, no inflammation, no peripheral palisading
Microscopic (histologic) images

Contributed by Kelly Magliocca, D.D.S., M.P.H.
Squamous odontogenic tumor

Squamous odontogenic tumor

SOT at scanning magnification

Benign islands of squamous epithelium within fibrous stroma

Epithelial vacuolization of squamous islands

Intraepithelial calcifications

Rounded contours of nests

Differential diagnosis
Additional references
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