Microbiology & parasitology


Dimorphic fungi

Talaromyces marneffei

Topic Completed: 1 December 2006

Minor changes: 21 March 2021

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PubMed Search: Talaromyces marneffei

Nat Pernick, M.D.
Page views in 2021 to date: 215
Cite this page: Pernick N. Talaromyces marneffei. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/microbiologypenicilliosis.html. Accessed October 15th, 2021.
Definition / general
  • Previously called Penicillium marneffei
  • Amphotericin B and itraconazole
Microscopic (histologic) description
  • Normo or hypercellular marrow
  • Intracytoplasmic organisms similar to histoplasma but also sausage cells with light blue cytoplasm and central cross walls (due to fission, not budding) and 1 or 2 purple red small nuclei
  • Normal or increased granulocyte and erythroid precursors
  • Normal megakaryocytes
Microscopic (histologic) images

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Giemsa stain: septate yeast-like cells

Penicillium (A / C)
vs. Histoplasma
(B / D)

Positive stains
Differential diagnosis
  • Histoplasmosis: budding, intracellular only, no septum; often different epidemiology
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