Oral cavity & oropharynx
Benign epithelial tumors & processes
Verruciform xanthoma
Author: Nat Pernick, M.D.
Last author update: 1 November 2013
Last staff update: 28 June 2023 (update in progress)
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Verruciform xanthoma oral
Table of Contents
Definition / general | Case reports | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosisCite this page: Pernick N Verruciform xanthoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavityverruciformxanthoma.html. Accessed September 30th, 2023.
Definition / general
- Rare lesion of oral mucosa
- Raised granular or verrucous lesion, usually of gingiva or alveolar ridge
- Reactive (Am J Surg Pathol 1998;22:479)
- Probably not HPV related (APMIS 2005;113:629, Arch Pathol Lab Med 2005;129:e62 but see Am J Dermatopathol 2000;22:447)
- References: Oral Oncol 2003;39:325
Case reports
- 57 year old man with papillary lesions on palate (Case of the Week #82)
- Multifocal lesion in upper aerodigestive tract of child with a systemic lipid disorder (Am J Surg Pathol 1989;13:309)
Treatment
- Excision; does not recur (J Formos Med Assoc 2007;106:141)
Gross description
- Raised granular or verrucous
Microscopic (histologic) description
- Foamy macrophages within dermal papillae covered by acanthotic or verrucous epithelium without atypia
Microscopic (histologic) images
Contributed by Kelly Magliocca D.D.S., M.P.H. and Case #82
Slightly papillary silhouette
Surface parakeratosis and histiocytes
Histiocytes
Palate lesions
Positive stains
- CD68, vimentin and factor XIII
Differential diagnosis
- Condyloma acuminatum:
- Prominent koilocytosis in upper epidermis, no prominent foamy macrophages
- Squamous cell carcinoma
- Verrucous carcinoma:
- Ulcerating or fungating lobules of mature squamous epithelium with minimal atypia, no prominent foamy macrophages
