Nonneoplastic placental conditions and abnormalities


Chronic histiocytic intervillositis

Last author update: 1 September 2011
Last staff update: 29 October 2020

Copyright: 2002-2024,, Inc.

PubMed Search: Chronic intervillositis OR massive chronic intervillositis

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Chronic histiocytic intervillositis. website. Accessed July 13th, 2024.
Definition / general
Gross description
  • Small placenta
Microscopic (histologic) description
  • Diffuse infiltrate of histiocytes within intervillous space with villous fibrinoid deposits
  • Other associated lesions may include atherosis, acute chorioamnionitis and rarely chronic villitis
  • Malaria: associated with abundant fibrin, black pigment, occasional neutrophils and parasite laden red blood cells
Positive stains
  • CD68 (histiocytic marker)
Negative stains
  • hCG (may be present in syncytiotrophoblasts but marked reduction compared to usual)
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