Placenta
Nonneoplastic placental conditions and abnormalities
Noninfectious
Massive perivillous fibrin deposition
Author: Mandolin S. Ziadie, M.D.
Last author update: 1 October 2011
Last staff update: 1 March 2024 (update in progress)
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Massive perivillous fibrin deposition
Table of Contents
Definition / general | Etiology | Gross description | Microscopic (histologic) descriptionCite this page: Ziadie MS. Massive perivillous fibrin deposition. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentamatfloorinfarct.html. Accessed April 26th, 2024.
Definition / general
- Massive deposition of intervillous fibrin that entrap the villi of the basal plate, extending to a thickness of at least 3 mm
- May be accompanied by massive perivillous fibrin deposition
- Associated with recurrent abortions / stillbirth, fetal growth restriction or neurologic impairment
- Seen in 0.09 - 0.5% of placentas
Etiology
- May be due to ischemic / infectious damage to deciduas basalis, including low maternal blood volume
- Associated with acute chorioamnionitis (Hum Pathol 1985;16:823)
Gross description
- Diffusely thick, stiff and pale basal plate
Microscopic (histologic) description
- Thick ( > 0.3 cm) bands of fibrin with intermingled trophoblast cells involve the entire basal plate and may extend up into the intervillous space
