Pleura & peritoneum

Pleura mesothelial tumors


Topic Completed: 1 November 2013

Minor changes: 11 January 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Biphasic mesothelioma pleura

See Also: Mesothelioma

Vaidehi Avadhani, M.D.
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Page views in 2021 to date: 1,183
Cite this page: Avadhani V. Mesothelioma-biphasic. website. Accessed December 2nd, 2021.
Definition / general
  • Biphasic / mixed: both epithelioid and sarcomatoid components, each at least 10%
  • May represent epithelial mesenchymal transition process (Mod Pathol 2012;25:86)
  • Biphasic pattern occurs in 30%, less common than epithelioid variant but more common than the pure sarcomatoid variant
Radiology images

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Low density mass in liver

Case reports
Gross images

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Firm, white lesion

Microscopic (histologic) description
  • Epithelioid and sarcomatoid areas, juxtaposed to each other or intermingled
Microscopic (histologic) images

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Biphasic tumor

H&E and immunostains

Various stains

Differential diagnosis
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