Skin nontumor
Spongiotic, psoriasiform and pustular reaction patterns
Lichen simplex chronicus

Topic Completed: 1 August 2011

Minor changes: 18 March 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Lichen simplex chronicus [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M. Lichen simplex chronicus. website. Accessed January 22nd, 2021.
Definition / general
  • Plaque like condition due to chronic rubbing and scratching
  • Also called neurodermatitis
Clinical features
  • Thick, scaly plaques with erythema, well demarcated from surrounding skin
  • Associated with excoriation, lichenification, crusting
  • Raised nodules are called prurigo nodularis
Microscopic (histologic) description
  • Marked hyperkeratosis associated with foci of parakeratosis
  • Prominent granular cell layer
  • The epidermal rete are elongated and irregularly thickened
  • Mild spongiosis
  • Perivascular and interstitial inflammation with histiocytes, lymphocytes and occasional eosinophils in superficial dermis
  • Occasionally enlarged elongated myofibroblasts, papillary dermal fibrosis, nerve hyperplasia
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