Skin nonmelanocytic tumor

Vascular tumors

Intravascular papillary endothelial hyperplasia

Last author update: 1 July 2012
Last staff update: 6 November 2020

Copyright: 2001-2023,, Inc.

PubMed search: intravascular papillary endothelial [title] hyperplasia

Related topic: Soft tissue chapter

Christopher S. Hale, M.D.
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Cite this page: Hale C. Intravascular papillary endothelial hyperplasia. website. Accessed June 9th, 2023.
Definition / general
  • Also called Masson hemangioma (Am J Dermatopathol 2003;25:71)
  • Often on fingers and in hemorrhoids
  • In skin, associated with preexisting pyogenic granuloma or hemangioma, vascular malformations or hemangiomas of blue rubber bleb nevus syndrome
  • Due to exuberant recanalization of a thrombus
  • May be secondary to trauma or superimposed on pyogenic granuloma or cavernous hemangioma
  • Slow growing, tender, blue red, deep dermal to subcutaneous mass
  • Rarely recurs after excision
Case reports
Microscopic (histologic) description
  • Dilated vessel contains papillary proliferation of plump endothelial cells without atypia overlying fibrous tissue
  • Fibrin deposition and thrombi present
  • Variable pleomorphism and stratification, no/rare mitotic figures, no necrosis, no solid cellular areas
Microscopic (histologic) images

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Histological features of IPEH

Differential diagnosis
  • Angiosarcoma: infiltrating, freely anastomosing channels lined by spindled to epithelioid endothelial cells with marked atypia, surrounding adnexae and dissecting dermal collagen
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