Skin nonmelanocytic tumor

• Found on the head and neck
• Usually affects older males

• IFK

• 24 year old woman with vulvar lesion (Int J Gynecol Pathol 2000;19:369)
• 55 year old woman with keratotic lesion of the lip (Pan Afr Med J 2014;18:304)

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• Patterns include:
  • Wart-like variant
  • Keratoacanthoma-like pattern
  • Solid nodular
• Well circumscribed endophytic growth of squamous cells with lobular extension into the dermis; exophytic lesions with a keratoacanthoma-like appearance have been described
• Variable number of squamous eddies; may be increased secondary to irritation
• Peripheral basaloid cells with occasional mitotic activity

Contributed by Andrew L.J. Dunn, M.D.

• Seborrheic keratosis
• Squamous cell carcinoma
• Tricholemmoma

Which of the following is true about inverted follicular keratosis?

1. BCL2 is downregulated in dendritic cells
2. Squamous eddies are an atypical finding in inverted follicular keratosis
3. These lesions are more commonly found on the head and neck
4. These lesions are more common in young women

C. These lesions are more commonly found on the head and neck

BCL2 has been found to be upregulated in the dendritic cells of IFKs but not seborrhea keratosis. IFKs are typically found on the head and neck of older males. Squamous eddies are a usual finding in IFKs.

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Reference: Inverted follicular keratosis