Soft tissue
Fibroblastic / myofibroblastic
Desmoplastic fibroblastoma

Topic Completed: 1 July 2012

Minor changes: 21 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Desmoplastic fibroblastoma

Komal Arora, M.D.
Page views in 2019: 3,152
Page views in 2020 to date: 1,847
Cite this page: Arora K. Desmoplastic fibroblastoma. website. Accessed August 6th, 2020.
Definition / general
  • Fibroblastic lesion centered in subcutaneous tissue with reactive fibroblasts, low cellularity and abundant collagen (Hum Pathol 1998;29:676)
  • Also called collagenous fibroma
  • Rare benign lesion of adult men (70% between ages 40 and 69 years)
  • Usually upper extremities, back, feet
Case reports
  • Conservative excision, does not recur or metastasize
Gross description
  • Usually 1 - 4 cm, well circumscribed, may be lobulated, has firm and homogeneous gray cut surface resembling cartilage
Gross images

Images hosted on other servers:

Well circumscribed tumor

Microscopic (histologic) description
  • Paucicellular, bland spindled (stellate) and reactive appearing fibroblasts and myofibroblasts separated by abundant collagen with variable myxoid stroma
  • Fibroblasts have amphophilic cytoplasm, vesicular nuclei and distinct nucleoli
  • 70% of cases involve subcutis, 25% extend into skeletal muscle
Microscopic (histologic) images

Images hosted on PathOut servers:

Large, reactive appearing spindled fibroblasts in fibrous matrix

Focus of low cellularity and dense collagen

More cellular area with reactive type fibroblasts

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
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