Soft tissue

Fibroblastic / myofibroblastic

Desmoplastic fibroblastoma

Topic Completed: 1 July 2012

Minor changes: 30 September 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Desmoplastic fibroblastoma

Komal Arora, M.D.
Page views in 2020: 3,358
Page views in 2021 to date: 2,910
Cite this page: Arora K. Desmoplastic fibroblastoma. website. Accessed October 21st, 2021.
Definition / general
  • Fibroblastic lesion centered in subcutaneous tissue with reactive fibroblasts, low cellularity and abundant collagen (Hum Pathol 1998;29:676)
  • Also called collagenous fibroma
  • Rare benign lesion of adult men (70% between ages 40 and 69 years)
  • Usually upper extremities, back, feet
Case reports
  • Conservative excision, does not recur or metastasize
Gross description
  • Usually 1 - 4 cm, well circumscribed, may be lobulated, has firm and homogeneous gray cut surface resembling cartilage
Microscopic (histologic) description
  • Paucicellular, bland spindled (stellate) and reactive appearing fibroblasts and myofibroblasts separated by abundant collagen with variable myxoid stroma
  • Fibroblasts have amphophilic cytoplasm, vesicular nuclei and distinct nucleoli
  • 70% of cases involve subcutis, 25% extend into skeletal muscle
Microscopic (histologic) images

AFIP images

Large, reactive
appearing spindled
fibroblasts in
fibrous matrix

Focus of low cellularity and dense collagen

More cellular area with reactive type fibroblasts

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
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