Soft tissue



Lymphangioma & lymphangiomatosis

Last author update: 1 November 2012
Last staff update: 27 January 2023 (update in progress)

Copyright: 2002-2023,, Inc.

PubMed Search: Lymphangioma soft tissue

See Also: Cystic, Lymphangiomatosis, Lymphangiomatous papules / plaques postradiation

Vijay Shankar, M.D.
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Cite this page: Shankar V. Lymphangioma & lymphangiomatosis. website. Accessed February 4th, 2023.
Definition / general
  • May represent malformations due to failure of lymphatics to communicate with venous system
  • Most described cases are cystic / cavernous
  • Skin tumors are called lymphangioma circumscriptum
  • Diffuse / multicentric lymphangiomas are often in thoracic cavity; also bone, extremities, soft tissue, viscera
Clinical features
Case reports
Clinical images

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Microscopic (histologic) description
  • Large lymphatic channels in loose connective tissue stroma
  • Focally disorganized smooth muscle in wall of larger channels
  • Peripheral lymphoid aggregates
  • Often increased mast cells (Mod Pathol 1999;12:569)
  • Lymphangiomatosis: increase in size and number of thin walled channels; lymphatic spaces are interconnecting and dilated, lined by a single attenuated layer of endothelial cells involving the dermis, subcutis and occasionally underlying fascia and skeletal muscle
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Various images

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Inferior bulbar conjunctiva






Negative stains
Electron microscopy description
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