Stains & CD markers

Editorial Board Members: Christian M. Schürch, M.D., Ph.D., Elizabeth Courville, M.D.
Anna Dusenbery, M.D.
Mark R. Wick, M.D.

Last author update: 5 May 2022
Last staff update: 5 May 2022

Copyright: 2002-2024,, Inc.

PubMed Search: SOX11

Anna Dusenbery, M.D.
Mark R. Wick, M.D.
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Cite this page: Dusenbery A, Wick MR. SOX11. website. Accessed February 22nd, 2024.
Definition / general
  • SRY (sex determining region Y) related high mobility group (HMG) box 11 (SOX11) is a member of the SOX gene family; specifically a member of the SOXC group of transcription factors
  • Located at chromosome 2p25.2 (Semin Cancer Biol 2020;67:3)
Essential features
  • Generally considered to be a marker for mantle cell lymphoma (MCL), although a subset of SOX11 negative MCL cases have also been described
  • Prognostic value is debated
Clinical features
Uses by pathologists
Prognostic factors
Microscopic (histologic) images

Contributed by Anna Dusenbery, M.D.
MCL of the tonsil MCL of the tonsil

MCL of the tonsil

Positive staining - normal
  • Not generally expressed in the nucleus of mature tissues; however, nuclear expression has been noted in Schwann cells, keratinocytes and other squamous or epithelial cells (Histopathology 2019;74:391, Blood 2008;111:800)
Positive staining - disease
Negative staining
Sample pathology report
Board review style question #1

Which of the following would be expected to show positive staining for SOX11 in a similar expression pattern to that depicted in the image shown above?

  1. Chronic lymphocytic leukemia / small lymphocytic lymphoma
  2. Leukemic nonnodal mantle cell lymphoma
  3. Marginal zone lymphoma
  4. Nonneoplastic lymphocytes
  5. Solid pseudopapillary neoplasm of the pancreas
Board review style answer #1
E. Solid pseudopapillary neoplasm of the pancreas

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Reference: SOX11
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