Stomach
Polyps
Juvenile polyp


Topic Completed: 1 August 2012

Minor changes: 1 September 2020

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PubMed Search: gastric juvenile polyp

Elliot Weisenberg, M.D.
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Page views in 2021 to date: 1,407
Cite this page: Weisenberg E. Juvenile polyp. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachjuvenile.html. Accessed May 15th, 2021.
Definition / general
  • Also called retention polyp
  • Part of generalized juvenile polyposis coli or rare gastric subtype, 20 - 50% of patients with syndrome have gastric polyps
  • Syndrome due to genetic dysregulation of TGF-β pathway
  • Associated with increased risk of colorectal and gastric carcinoma
Gross description
  • Smooth surfaced, 1 - 2 cm, short narrow stalk
Microscopic (histologic) description
  • Irregular cysts in lamina propria with normal gastric epithelium
  • Surface and foveolar hyperplasia, may have stromal hemorrhage, surface ulceration and chronic inflammation due to torsion
Microscopic (histologic) images

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Gastric juvenile polyp

Differential diagnosis
  • Hyperplastic polyp: usually background mucosal disease, may need clinical or family history for definitive diagnosis
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