Stomach
Neuroendocrine tumors
Neuroendocrine-classification
Author: Elliot Weisenberg, M.D.
Last author update: 1 August 2012
Last staff update: 1 September 2020
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: stomach neuroendocrine neoplasms
Cite this page: Weisenberg E. Neuroendocrine-classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachneuroendocrineclassification.html. Accessed September 30th, 2023.
Classification
2019 WHO classification
- Neuroendocrine tumor (NET):
- NET, grade 1 (G1): well differentiated low grade
- NET, G2: well differentiated intermediate grade
- NET, G3: well differentiated high grade
- Neuroendocrine carcinoma, small cell type (SCNEC)
- Neuroendocrine carcinoma, large cell type (LCNEC)
- Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN)
- Grading of well differentiated neuroendocrine tumors:
- Well differentiated NET, G1: mitotic rate (mitoses/mm2) < 2 and Ki67 < 3%
- Well differentiated NET, G2: mitotic rate (mitoses/mm2) 2 - 20, Ki67 < 3 - 20% (use highest grade to categorize)
- Well differentiated NET, G3: mitotic rate (mitoses/mm2) > 20, Ki67 > 20% (use highest grade to categorize)
- Poorly differentiated neuroendocrine carcinoma:
- Mitotic rate (mitoses/2 mm2) > 20 or Ki67 index > 20%
Positive stains
