Stomach
Neuroendocrine tumors
Neuroendocrine-classification


Topic Completed: 1 August 2012

Minor changes: 1 September 2020

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PubMed Search: stomach neuroendocrine neoplasms

Elliot Weisenberg, M.D.
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Table of Contents
Classification | Positive stains
Cite this page: Weisenberg E. Neuroendocrine-classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachneuroendocrineclassification.html. Accessed May 15th, 2021.
Classification
2019 WHO classification
  • Neuroendocrine tumor (NET):
    • NET, grade 1 (G1): well differentiated low grade
    • NET, G2: well differentiated intermediate grade
    • NET, G3: well differentiated high grade
  • Neuroendocrine carcinoma, small cell type (SCNEC)
  • Neuroendocrine carcinoma, large cell type (LCNEC)
  • Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN)
  • Grading of well differentiated neuroendocrine tumors:
    • Well differentiated NET, G1: mitotic rate (mitoses/mm2) < 2 and Ki67 < 3%
    • Well differentiated NET, G2: mitotic rate (mitoses/mm2) 2 - 20, Ki67 < 3 - 20% (use highest grade to categorize)
    • Well differentiated NET, G3: mitotic rate (mitoses/mm2) > 20, Ki67 > 20% (use highest grade to categorize)
  • Poorly differentiated neuroendocrine carcinoma:
    • Mitotic rate (mitoses/2 mm2) > 20 or Ki67 index > 20%
Positive stains
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