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Bone chapter (nontumor and tumor)
Other tumors of bone
Giant cell tumor

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 August 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See subtypes below: benign metastasizing giant cell tumormalignant giant cell tumor

General
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Xray description
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Radiology images
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Destructive sacral lesion with rim of reactive bone

Distal femur MRI - contributed by Dr. Mark R. Wick

Proximal tibia xray - contributed by Dr. Mark R. Wick


Radius xray - contributed by Dr. Mark R. Wick

Tibial giant cell tumor

Chest radiograph

Case reports
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Treatment
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Gross description
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Gross images
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Contributed by Dr. Mark R. Wick

Distal femur - contributed by Dr. Mark R. Wick

Proximal femur - contributed by Dr. Mark R. Wick

Distal femur

Micro description
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Micro images
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Low power

Multinucleated giant cell

Advancing metaphyseal margin

Osseous giant cell tumor


Contributed by Dr. Mark R. Wick

Pulmonary metastasis


Giant cells in background of spindled mononuclear cells

Anaplastic-like changes

H&E, HAM56+, MiTF+, TRAP+


Classic features

Quiz case

Multinucleated giant cells and mononuclear cells

Comparison with giant cells in other disorders


Ki-67 staining in mononuclear cells

Cyclin D1 nuclear staining of giant cells

Cytology images
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Multinucleated giant cells and hemorrhage

Positive stains
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Electron microscopy description
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Differential diagnosis
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Additional references
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Benign metastasizing giant cell tumor

General
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Case reports
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Gross description
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Micro description
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Micro images
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Figure 1: original tumor with large multinucleated giant cells; multiple lung nodules on Xray
3/4: lung nodules show reactive bone with variable fibrosis but no giant cells


Chest Xray, H&E of lung metastasis



Malignant giant cell tumor

General
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Case reports
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Micro description
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End of Bone chapter (nontumor and tumor) > Other tumors of bone > Giant cell tumor


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