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General
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Terminology
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Epidemiology
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Clinical features
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Radiology
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Case reports
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Treatment and prognosis
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Clinical images
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MRI - courtesy of Dr. Mark R. Wick

Hemorrhagic lesion

Post-radiotherapy

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Courtesy of Dr. Mark R. Wick

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Post radiation - courtesy of Dr. Mark R. Wick

Gross description
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Gross images
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Contributed by Dr. Mark R. Wick

Breast skin - contributed by Dr. Mark R. Wick

Well circumscribed mass (AFIP)

Mastectomy post radiation and chemotherapy for ductal carcinoma

Micro description
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Micro images
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Neoplastic vascular channels

Solid areas and neoplastic vascular channels

Markedly pleomorphic tumor cells

Focal spindle cells

Various images

Fig 1: Infiltrating vascular lesion; Fig 2/3: Pleomorphic spindle cells

Low grade tumor recurring as high grade tumor



Low grade angiosarcoma:



Intermediate grade angiosarcoma:

Dilated vascular spaces contain endothelial cells and red blood cells

Focal solid neoplastic vascular proliferation in fat

Focal spindle cell and small vessel proliferation

Focal complex capillary and endothelial cell proliferation

Spindle cells and mitotic figure



High grade angiosarcoma:

Irregular spaces resemble adenocarcinoma

High grade tumor

Anastomosing vascular channels with spindle and papillary foci

Solid growth and hemorrhagic necrosis

Spindle cells with indistinct vascular spaces

Plump spindle cells with mitoses

Blood lakes (foci of hemorrhagic necrosis)

Highly anaplastic endothelial cells



Post-mastectomy (AFIP):

Atypical vascular proliferation in dermis and subcutis and changes of chronic lymphedema

Vascular channels in superficial dermis with endothelial atypia

Anastomosing vascular channels with papillary proliferation of atypical endothelial cells

Focal solid pattern of atypical endothelial cells



Post-radiotherapy:

Skin tumor



Stains:

H&E, Ki-67 and Skp2

Factor VIII-related antigen



Contributed by Dr. Mark R. Wick:

Epithelioid

Breast skin

CD31

FlI1

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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Additional references
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End of Breast malignant, males, children > Sarcoma > Angiosarcoma


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