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CD Markers
CD1

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 23 August 2013, last major update July 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

See also   CD1aCD1bCD1cCD1dCD1e   below

General
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Physiology
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Clinical features
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Uses by pathologists
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Micro images
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Primary and metastatic melanoma

Langerhans’ cells of anal mucosa




CD1a
Sources of CD1a (advertisements):

General
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Clinical features
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Uses by pathologists
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Micro images
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Langerhans cell histiocytosis:

Brain

Ear (fig B)

Femur


Lung: right is bronchioalveolar lavage

Mandible


Orbit

Rib (fig 3)

Skin


Skull-cytology

Thyroid gland

Unknown site


Extraosseous LCH


Congenital self-healing tumor (fig 4)



Other:

Esophagus: Barrett's metaplasia

Oral cavity: gingiva-normal and diseased


Skin: normal

Skin: dysplastic nevus with dermal
melanosis and fibrosis (fig B)


Skin: mycosis fungoides


Thymus: normal



Positive staining - normal
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Positive staining - nontumor
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Positive staining - tumor
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Negative staining
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Electron microscopy images
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Langerhans cell histiocytosis: Birbeck granules




CD1b

General
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Diagrams
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MHC class I-related lipid-binding proteins

Uses by pathologists
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Micro images
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Leprosy patient

Thymus tissue

Urinary bladder shows strong cytoplasmic
positivity in urothelial cells


Positive staining - normal
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Positive staining - disease
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Negative staining
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CD1c

General
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Clinical features
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Uses by pathologists
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Micro images
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Skin: dermal dendritic cells

Skin: dermal dendritic cells (fig c)

Spleen: marginal zone B cells

Stomach: H. pylori+ mucosa

Thyroid gland


Immature dendritic cells

Adenocarcinoma: left-ovary, right-endometrium

Positive staining - normal
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Positive staining - disease
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Negative staining
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Electron microscopy description
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Electron microscopy images
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Found in various cellular locations




CD1d

General
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Diagrams
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Antigen presentation

Viral evasion of antigen presentation


Intestinal epithelial CD1d expression

Clinical features
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Uses by pathologists
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Case reports
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Micro images
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Cervix: HPV associated lesions

Lymph node: paracortical
dendritic cells (fig 2)

Placenta: trophoblast


Skin: scalp

Skin: dendritic antigen presenting cells (fig d)

Positive staining - normal
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Positive staining - disease
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Negative staining
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CD1e

General
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Clinical features
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Uses by pathologists
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Positive staining - normal
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End of CD Markers > CD1
Ref Updated: 7/24/13


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