CD Markers - CD1e

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CD Markers

Cd1e

Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 26 November 2010, last major update November 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.

General
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● On chromosome 1q22-23 (not MHC linked); noncovalently associated with beta2 microglobulin

Physiology
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● Not expressed on cell surface
● Part of immune response to intracellular bacteria
● Processes mycobacterial antigen (instead of presenting antigen directly), and helps expand repertoire of glycolipid T cell antigens to optimize the immune response (Science 2005;310:1321); presentment is done by CD1b
● Initially accumulates in Golgi of immature dendritic cells or transfected cells as a membrane-associated form, then is transported to early and then late endosomes, then is cleaved into a soluble form, which facilitates the processing of glycolipids presented by other CD1 molecules transiting through the same compartments (Biochem J 2009;419:661)
● +6129 A/G gene polymorphisms are associated with multiple sclerosis (Immunol Invest 2010;39:874)

Uses by pathologists
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● No significant clinical use by pathologists

Positive staining (normal)
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● Dendritic cells

Additional references
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● MIM 188411

End of CD Markers > CD1e

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