Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 28 July 2013, last major update July 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Participates in lipid antigen presentation without interacting with T cell receptor; binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens; may positively or negatively affect lipid presentation by CD1b, CD1c, CD1d (Proc Natl Acad Sci USA 2011;108:14228)
- Only CD1 protein existing in soluble form in late endosomes of dendritic cells; not expressed on cell surface
- On chromosome 1q22-23 (not MHC linked); non-covalently associated with beta2 microglobulin
- Processes mycobacterial antigen (instead of presenting antigen directly) and may help expand repertoire of glycolipid T cell antigens to optimize the immune response (Science 2005;310:1321, Proc Natl Acad Sci USA 2011;108:13230); presentment is done by CD1b (J Biol Chem 2012;287:31494)
- Initially accumulates in Golgi of immature dendritic cells or transfected cells as a membrane-associated form, then is transported to early and then late endosomes, then is cleaved into a soluble form, which facilitates the processing of glycolipids presented by other CD1 molecules transiting through the same compartments (Biochem J 2009;419:661)
- +6129 A/G gene polymorphisms are associated with multiple sclerosis (Immunol Invest 2010;39:874)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
End of CD Markers > CD1e
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