CD Markers
CD60 (CDw60)

Reviewer: Nat Pernick, M.D. (see Authors page)

Revised: 28 December 2015, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

PubMed Search: CD60

Related topics: CD60a, CD60b, CD60c
Cite this page: CD60 (CDw60). website. Accessed October 28th, 2016.
Definition / General
  • Use of CD60, CDw60 and CD60a, CD60b and CD60c is inconsistent
  • Not proteins, but oligosaccharides present on gangliosides
  • CD60a: GD3 - carbohydrate structure
  • CD60b: 9-O-acetyl-GD3 - carbohydrate structure
  • CD60c: 7-O-acetyl-GD3 - carbohydrate structure
  • Antibodies provide costimulatory signals for T cells
  • Expressed on most T cells in autoimmune lesions (Immunol Invest 2001;30:67)
  • CD8+ CD60+ T cells may regulate IgE memory responses and isotype switching (Hum Immunol 2005;66:1029)
  • Associated with Th1 immune response in skin (Br J Dermatol 2003;149:739)
  • Reference: Glycolipid
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Platelets, T cells (30%, Carbohydr Res 2000;329:791), thymic epithelium, activated keratinocytes, melanocytes, synovial fibroblasts, glomeruli, smooth muscle cells and astrocytes
  • Also epithelium of reproductive system, exocrine and endocrine glands (Histochem J 2000;32:447)
Positive Staining - Disease
Negative Staining
  • B cells, granulocytes and monocytes