CD Markers
CD60 (CDw60)


Topic Completed: 1 February 2002

Revised: 24 October 2019

Copyright: (c) 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: CD60

Nat Pernick, M.D.
Page views in 2018: 60
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Cite this page: Pernick N. CD60 (CDw60). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd60.html. Accessed December 12th, 2019.
Definition / general
  • Use of CD60, CDw60 and CD60a, CD60b and CD60c is inconsistent
  • Not proteins, but oligosaccharides present on gangliosides
  • Antibodies provide costimulatory signals for T cells
  • Expressed on most T cells in autoimmune lesions (Immunol Invest 2001;30:67)
  • CD8+ CD60+ T cells may regulate IgE memory responses and isotype switching (Hum Immunol 2005;66:1029)
  • Associated with Th1 immune response in skin (Br J Dermatol 2003;149:739)
  • Reference: Glycolipid
CD60a
  • GD3 - carbohydrate structure
  • Not a protein: oligosaccharide present on gangliosides
  • No significant clinical use by pathologists
CD60b
  • 9-O-acetyl-GD3 - carbohydrate structure
  • Intracellular regulators of apoptosis in T lymphocytes (Glycobiology 2011;21:1161)
  • Expressed during rat central nervous system development and mainly associated with neuronal migration (Stem Cells Int 2017;2017:5759490)
  • Other names: UM4D4
  • Positive stains: subsets of CD4+ and CD8+ peripheral T cells, platelets and monocytes
CD60c
  • 7-O-acetyl-GD3 - carbohydrate structure
  • Not a protein: oligosaccharide present on gangliosides
  • No significant clinical use by pathologists
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Platelets, T cells (30%, Carbohydr Res 2000;329:791), thymic epithelium, activated keratinocytes, melanocytes, synovial fibroblasts, glomeruli, smooth muscle cells and astrocytes
  • Also epithelium of reproductive system, exocrine and endocrine glands (Histochem J 2000;32:447)
Positive staining - disease
Negative staining
  • B cells, granulocytes and monocytes
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