Sarcoma / lymphoma / other
Malignant mixed Müllerian tumor (MMMT)

Topic Completed: 1 May 2007

Revised: 28 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Malignant mixed Müllerian tumor cervix

Branko Perunovic D.M.
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Cite this page: Perunovic B. Malignant mixed Müllerian tumor (MMMT) . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixMMMT.html. Accessed October 19th, 2019.
Definition / general
  • Also called malignant mixed mesodermal tumor or carcinosarcoma (if homologous)
  • Rare, < 100 reported cases, less common than leiomyosarcoma
  • Most tumors of cervix are extensions from endometrium; may be secondary to radiation therapy for cervical squamous cell carcinoma
  • Mean age 50 to 65 years, range 12 to 93 years
  • Often confined to uterus at presentation with better prognosis
Case reports
Gross description
  • Polypoid mass with variable necrosis
Microscopic (histologic) description
  • May resemble uterine tumor
  • Neoplastic epithelial and mesenchymal components
  • Usually accompanied by high grade squamous intraepithelial lesion
  • Invasive epithelial component may be adenoid basal, adenoid cystic, basaloid squamous cell or keratinizing squamous cell but is usually NOT adenocarcinoma
  • Sarcomatous component usually homologous resembling fibrosarcoma or endometrial stromal sarcoma, often with prominent myxoid change (Int J Gynecol Pathol 1998;17:211)
  • Heterologous component is usually rhabdomyosarcoma, present in 50%; also chondrosarcoma, liposarcoma
Cytology description
Positive stains
Molecular / cytogenetics description
Differential diagnosis
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