WHO grading of astrocytomas (2000)
Reviewer: Eman Abdelzaher, M.D., Ph.D. (see Reviewers page)
Revised: 26 April 2013, last major update March 2012
Copyright: (c) 2005-2013, PathologyOutlines.com, Inc.
- Pilocytic (grade I): circumscribed, biphasic, bipolar and multipolar cells, Rosenthal fibers, microcysts, granular bodies; no/rare mitotic figures, no/rare vascular proliferation, no/focal necrosis
- Diffuse (grade II): moderately hypercellular, monotonous cells, mild nuclear atypia, no/minimal mitotic activity
- Anaplastic (grade III): increased cellularity and diffuse infiltration, increased nuclear atypia, increased mitotic activity
- Glioblastoma (grade IV): vascular proliferation, necrosis, crowded anaplastic cells, marked nuclear atypia, brisk mitotic activity
End of CNS tumor > Astrocytic tumors > WHO grading of astrocytomas (2000)
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