Metastases to colon
Reviewers: Charanjeet Singh, M.D. (see Reviewers page)
Revised: 16 October 2011, last major update September 2011
Copyright: (c) 2003-2011, PathologyOutlines.com, Inc.
● Common primaries are lung (large cell), melanoma, prostate (by extension), breast, stomach and ovary
Primary sites of metastases to colon
● Bladder: case report of signet ring carcinoma (Dig Liver Dis 2006;38:609)
● Breast: rare (Tech Coloproctol 2004;8 Suppl 1:s135)
● Endometrial stromal sarcoma: may resemble GIST, but plump spindle cells with invasive tongues at periphery and angiovascular invasion; also CD10+, CD117-
● Endometrioid adenocarcinoma: associated with endometriosis
● Leukemia: usually involves right colon and terminal ileum; polypoid or transmural infiltrates
● Melanoma: may have long time interval between primary and metastases
Case reports: unknown primary site (The Internet Journal of Gastroenterology 2006;4:Number 2)
Micro images: tumor cells in submucosa
Positive stains: HMB45, MelanA/Mart1 and S100
● Prostate: infiltrative into submucosa; no in situ or intramucosal carcinoma; classic prostate histology; resections for rectal cancer rarely contain nodes with metastatic prostate carcinoma
● Stomach: linitis plastica type metastases may resemble poorly differentiated carcinoma (Kaohsiung J Med Sci 2004;20:552)
● Central ulceration extending towards mucosa, but often sparing it
● General: no in situ or mucosal malignancy
● Melanoma: usually multiple submucosal metastases with normal overlying mucosa; undifferentiated epithelial neoplasm with discohesive cells with pink cytoplasm, large nucleoli
End of Colon tumor > Carcinoma > Metastases to colon
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