Benign tumors
Squamous papilloma

Topic Completed: 1 February 2013

Revised: 11 March 2020

Copyright: 2003-2019,, Inc.

PubMed Search: Squamous papilloma[TIAB] esophagus

Elliot Weisenberg, M.D.
Page views in 2019: 7,888
Page views in 2020 to date: 1,892
Cite this page: Weisenberg E. Squamous papilloma. website. Accessed April 8th, 2020.
Definition / general
  • Benign polyp of mature stratified squamous epithelium overlying lamina propria
Clinical features
Gross description
  • Small (5 mm or less), whitish pink sessile mass
Microscopic (histologic) description
  • Exophytic (most common), endophytic and spiked patterns described
  • Mature thickened squamous epithelium covering delicate fibrovascular stalks which may be branching, endophytic or with stromal spikes
  • May have koilocytosis, parakeratosis and binucleated cells suggestive of HPV infection; HPV infection especially common in exophytic lesions
Microscopic (histologic) images

AFIP images

Elaborate branching of lamina propria

Endophytic type

Spike form

Images hosted on other servers:

Various images


Differential diagnosis
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