Benign tumors
Squamous papilloma

Author: Elliot Weisenberg, M.D. (see Authors page)

Revised: 18 January 2018, last major update February 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: Squamous papilloma[TIAB] esophagus

Cite this page: Weisenberg, E. Squamous papilloma. website. Accessed November 17th, 2018.
Definition / general
  • Benign polyp of mature stratified squamous epithelium overlying lamina propria
Clinical features
Gross description
  • Small (5 mm or less), whitish pink sessile mass
Microscopic (histologic) description
  • Exophytic (most common), endophytic and spiked patterns described
  • Mature thickened squamous epithelium covering delicate fibrovascular stalks which may be branching, endophytic or with stromal spikes
  • May have koilocytosis, parakeratosis and binucleated cells suggestive of HPV infection; HPV infection especially common in exophytic lesions
Microscopic (histologic) images

Images hosted on PathOut server:

Elaborate branching of lamina propria

Endophytic type

Spike form

Images hosted on other servers:

Various images


Differential diagnosis