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Liver and intrahepatic bile ducts-nontumor

Hepatitis - noninfectious

Granulomatous hepatitis – noninfectious

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 30 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


● Granulomatous liver disease (infectious and non-infectious) in 4% of liver biopsies (Clin Liver Dis 2010;14:605)
● See also Granulomatous hepatitis - infectious
Chronic granulomatous disease of childhood: necrotizing poorly formed granulomas with lipofuscin in histiocytes
Crohn’s disease: see topic
Drug/toxin induced hepatitis: see topic
Foreign material: periportal talc or other material from intravenous drug abusers, periportal silicone in dialysis patients, amyloid
Idiopathic: 10% of all granulomatous disease (infectious and non-infectious); numerous non-caseating granulomas, usually lobular; may precede sarcoidosis; a diagnosis of exclusion; good prognosis if remain in idiopathic group after workup; some patients may require corticosteroids (J Clin Pathol 2003;56:850)
Lipogranulomas: usually centrilobular, contain lipid, variable steatosis in adjacent liver; may be a response to endogenous and dietary lipid; no additional evaluation required
Malignancy: epithelioid granulomas occur in Hodgkin’s lymphoma and other malignancies, but do not imply metastatic spread
Primary biliary cirrhosis: see topic
Sarcoidosis: see topic

Micro images

Multiple non-caseating granulomas and typical Langerhans giant cells

Fibrin-ring granuloma: fat vacuole surrounded by ring of fibrin deposition and epithelioid cells

Due to sulfa drugs

End of Liver and intrahepatic bile ducts-nontumor > Hepatitis - noninfectious > Granulomatous hepatitis – noninfectious

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