Mediastinum
Thymic neuroendocrine tumor
Neuroendocrine carcinoma


Topic Completed: 1 December 2012

Minor changes: 5 December 2019

Copyright: 2003-2019, PathologyOutlines.com, Inc.

PubMed Search: Neuroendocrine carcinoma mediastinum

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Neuroendocrine carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumneuroendocrinecarcinoma.html. Accessed September 19th, 2020.
Definition / general
  • Similar to neuroendocrine carcinomas at other sites
  • Aggressive neoplasms capable of local recurrence and distant metastasis (Ann Pathol 2005;25:205)
Terminology
  • Atypical carcinoids are considered moderately differentiated neuroendocrine carcinomas
  • Undifferentiated or poorly differentiated neuroendocrine carcinomas may be small cell carcinoma
Clinical features
Case reports
Microscopic (histologic) description
  • Larger cells with more cytoplasm than small cell carcinoma, organoid growth pattern, spindle cell foci
  • May have prominent angiomatoid features (Hum Pathol 1999;30:635)
Microscopic (histologic) images

Images hosted on other servers:

Nests of cells with
uniform nuclei and
finely granular
chromatin

Nests, ribbons and festoons

Various stains

Negative stains
Electron microscopy description
  • Desmosomes, neurosecretory granules
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