Oral cavity
Congenital anomalies
Epulis

Author: Charu Thakral, M.D. (see Authors page)

Revised: 7 February 2017, last major update January 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: epulis oral cavity
Cite this page: Epulis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityepulis.html. Accessed February 24th, 2017.
Definition / General
  • Congenital granular cell tumor of alveolar mucosa of jaw in newborns
  • 90% girls; 10% present as multiple lesions
  • Doesn’t recur, even if incompletely excised
  • 0.5 - 2 cm soft, pedunculated mucosal mass
  • Spontaneously regresses over first 8 months of life (Am J Surg Pathol 1981;5:37)
Terminology
  • Congenital granular cell myoblastoma, granular cell epulis of infancy and granular cell fibroblastoma
Sites
  • Exclusively on anterior alveolar ridge of maxilla and mandible, usually overlying future canine and lateral incisor teeth
Case Reports
Clinical Images

Images hosted on PathOut server:

2 day old girl with difficulty eating
and breathing due to upper jaw lesion,
contributed by Dr. Dhiraj B. Nikumbh



Images hosted on other servers:

Lesion at 3 weeks

Lesion at 16 months

Tumor arising from anterior maxillary alveolus

Mass protruding from mouth

Gross Images

Images hosted on PathOut server:

Congenital granular
cell tumor, contributed
by Dr. Dhiraj B. Nikumbh



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Homogenous appearance

Micro Description
  • Confluent to nodular submucosal growth of tumors composed of large polygonal cells with eosinophilic granular cytoplasm and small central nuclei
  • Overlying epithelium is atrophic; does NOT show pseudoepitheliomatous hyperplasia (common with granular cell tumor of adults)
Micro Images

Images hosted on PathOut server:

Contributed by Dr. Dhiraj B. Nikumbh:

Tissue bits lined by
stratified squamous
epithelium,
tumor is beneath

Tumor composed of cells having abundant
granular eosinophilic cytoplasm
with monomorphic vesicular nuclei
with inconspicuous nucleoli


S100



Images hosted on other servers:

Polygonal cells with granular cytoplasm and small round nuclei

Meshwork of delicate blood vessels

Positive Stains
Negative Stains
Electron Microscopy Images

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Granules and lysosomes

Differential Diagnosis