Oral cavity
Congenital anomalies
Epulis

Author: Charu Thakral, M.D. (see Authors page)

Revised: 13 April 2018, last major update January 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Epulis[TI] oral cavity[mh]
Cite this page: Thakral, C. Epulis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/oralcavityepulis.html. Accessed August 17th, 2018.
Definition / general
  • Congenital granular cell tumor of alveolar mucosa of jaw in newborns
  • 90% girls; 10% present as multiple lesions
  • Doesn't recur, even if incompletely excised
  • 0.5 - 2 cm soft, pedunculated mucosal mass
  • Spontaneously regresses over first 8 months of life (Am J Surg Pathol 1981;5:37)
Terminology
  • Congenital granular cell myoblastoma, granular cell epulis of infancy and granular cell fibroblastoma
Sites
  • Exclusively on anterior alveolar ridge of maxilla and mandible, usually overlying future canine and lateral incisor teeth
Case reports
Clinical images

Images hosted on PathOut server:

Contributed by Dr. Dhiraj B. Nikumbh:

2 day old girl with
difficulty eating and
breathing due to
upper jaw lesion



Images hosted on other servers:

Lesion at 3 weeks

Lesion at 16 months

Tumor arising from anterior maxillary alveolus

Mass protruding from mouth

Gross images

Images hosted on PathOut server:

Contributed by Dr. Dhiraj B. Nikumbh:

Congenital granular cell tumor



Images hosted on other servers:

Homogenous appearance

Microscopic (histologic) description
  • Confluent to nodular submucosal growth of tumors composed of large polygonal cells with eosinophilic granular cytoplasm and small central nuclei
  • Overlying epithelium is atrophic; does NOT show pseudoepitheliomatous hyperplasia (common with granular cell tumor of adults)
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Dr. Dhiraj B. Nikumbh:

Tissue bits lined
by stratified
squamous epithelium,
tumor is beneath

Tumor composed of cells having
abundant granular eosinophilic
cytoplasm with monomorphic vesicular
nuclei with inconspicuous nucleoli

S100



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Polygonal cells with granular cytoplasm and small round nuclei

Meshwork of delicate blood vessels

Positive stains
Negative stains
Electron microscopy images

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Granules and lysosomes

Differential diagnosis