Pancreas - Acinar cell cystadenoma

Home Chapter Home Jobs Conferences Fellowships Books

Pancreas

Tumors

Acinar cell cystadenoma

Reviewer: Deepali Jain, M.D. (see Reviewers page)
Revised: 25 November 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
=========================================================================

● Either clinically recognized macroscopic or incidental microscopic (WHO)
● First described in 2002 (Am J Surg Pathol 2002;26:698)
● Rare benign cystic neoplasm of the pancreas (Pancreas 2008;37:254, Am J Surg Pathol 2012;36:1579)
● 70% women, ages 16 to 66 years
● Benign behavior

Case reports
=========================================================================

● 24 year old woman with 6 cm cystic lesion in the head of the pancreas (Case of the Week #136)
● 52 year old man with incidental tumor (Am J Clin Pathol 2002;118:211)

Treatment
=========================================================================

● Excision

Gross description
=========================================================================

● Mean 6 cm, unilocular or multilocular cysts with watery fluid, cysts usually not connected with ductal system

Gross images
=========================================================================

Various images

Micro description
=========================================================================

● Well circumscribed, mature acinar cells with abundant eosinophilic granular cytoplasm and round, basal nuclei
● Cyst lined by flattened cells resembling normal ductal epithelium, but with focal acinar cells and admixed with dilated acini
● May be adjacent to mucinous ductal epithelium
● Eosinophilic secretions form oval plugs
● No papillary projections or solid areas, no ovarian type stroma, no PanIN lesions
● No atypia, no mitotic activity, no vascular invasion, no relationship to major ductal system (Stanford University)

Micro images
=========================================================================

Case of the week #136: H&E and trypsin

Various images

Positive stains
=========================================================================

● PAS, lipase, trypsin, chymotrypsin, CK7

Negative stains
=========================================================================

● Ki-67

Electron microscopy images
=========================================================================

Case of the week 136

Differential diagnosis
=========================================================================

● Acinar cell cystadenocarcinoma: more complex epithelium, nuclear atypia, prominent nucleoli; often necrosis, solid nests of tumor cells, mitotic figures, infiltration into surrounding stroma)
● PanIN: no acinar cells, variable atypia

End of Pancreas > Tumors > Acinar cell cystadenoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).