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Prostate

Prostatitis

Malakoplakia

Reviewers: Gladell Paner, M.D., (see Reviewers page)
Revised: 31 January 2012, last major update January 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● May involve prostate, usually associated with bladder disease (Int J Surg Pathol 2007;15:86)
● Ages 47+
● Represents a peculiar form of tissue reaction to bacterial infection, most commonly gram negative bacterias (e.g. Escherichia coli and Klebisella pneumonia)
● Usually periductal, may resemble carcinoma on ultrasound, may actually coexist with carcinoma
● Prostate enlarged on clinical examination, suggestive of carcinoma

Micro images
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Prostate glands replaced by histiocytes, lymphocytes and plasma cells; Michelis-Gutmann bodies are present

Differential diagnosis
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● Granulomatous prostatitis with abundant histiocytes: has granulomas but no Michaelis-Gutmann bodies (better highlighted with von Kossa stain)

End of Prostate > Prostatitis > Malakoplakia

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