Authors: Gladell Paner, M.D. (see Authors page)

Revised: 19 July 2016, last major update January 2012

Copyright: (c) 2003-2016,, Inc.

PubMed Search: Malakoplakia[title] prostatic
Definition / General
  • May involve prostate, usually associated with bladder disease (Int J Surg Pathol 2007;15:86)
  • Ages 47+
  • Represents a peculiar form of tissue reaction to bacterial infection, most commonly gram negative bacterias (e.g. Escherichia coli and Klebisella pneumonia)
  • Usually periductal, may resemble carcinoma on ultrasound, may actually coexist with carcinoma
  • Prostate enlarged on clinical examination, suggestive of carcinoma
Micro Images

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Prostate glands replaced by histiocytes, lymphocytes
and plasma cells; Michelis-Gutmann bodies are present

Differential Diagnosis