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Prostate

Microscopic mimics of prostatic carcinoma

Partial atrophy


Reviewer: Komal Arora, M.D., (see Reviewers page)
Revised: 26 June 2012, last major update June 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Benign prostate glands with relatively scant cytoplasm, but the glands are not fully atrophic and do not appear basophilic at low magnification
● Basal cells absent/hard to identify (63%)
● Irregular (crinkled) nuclei frequent/occasional (57%), regular atrophy (35%), frequent nucleoli (25%), no intraluminal crystalloids or blue-tinged mucinous secretions noted (Am J Surg Pathol 1998;22:440, Am J Surg Pathol 2008;32:851, Am J Surg Pathol 2008;32:58)
● Associated with adenocarcinoma or glands suspicious for cancer in other cores (16%)

Micro images
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Various images

Positive stains
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● AMACR (variable expression)

Negative stains
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● Focal absence of basal markers (HMCK, p63)

Differential diagnosis
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● Low grade adenocarcinoma: more cytoplasm, no crinkled nuclei, cytoplasm differs from adjacent glands, no adjacent atrophy

End of Prostate > Microscopic mimics of prostatic carcinoma > Partial atrophy


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