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Microscopic mimics of prostatic carcinoma

Partial atrophy

Reviewer: Komal Arora, M.D., (see Reviewers page)
Revised: 21 May 2014, last major update June 2012
Copyright: (c) 2003-2014, PathologyOutlines.com, Inc.


● Benign prostate glands with relatively scant cytoplasm, but the glands are not fully atrophic and do not appear basophilic at low magnification
● Basal cells absent/hard to identify (63%)
● Irregular (crinkled) nuclei frequent/occasional (57%), regular atrophy (35%), frequent nucleoli (25%), no intraluminal crystalloids or blue-tinged mucinous secretions noted (Am J Surg Pathol 1998;22:440, Am J Surg Pathol 2008;32:851, Am J Surg Pathol 2008;32:58)
● Associated with adenocarcinoma or glands suspicious for cancer in other cores (16%)

Micro images

Various images

Positive stains

● AMACR (variable expression)

Negative stains

● Focal absence of basal markers (HMCK, p63)

Differential diagnosis

● Low grade adenocarcinoma: more cytoplasm, no crinkled nuclei, cytoplasm differs from adjacent glands, no adjacent atrophy

End of Prostate > Microscopic mimics of prostatic carcinoma > Partial atrophy

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