Infectious / inflammatory disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- May cause spontaneous splenic rupture and death, often 10-21 days after disease onset
- Rupture may be due to increased intrasplenic pressure due to congestion and weakening of splenic capsule from infiltration by immunoblasts
Grossly enlarged with haematoma|
- Expansion of red pulp with immunoblastic proliferation
- Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells, infiltrate subintima of intratrabecular veins, occasionally exhibit hemophagocytosis
- Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
End of Spleen > Infectious / inflammatory disorders > Infectious mononucleosis
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