Infectious / inflammatory disorders
Infectious mononucleosis

Author: Jaleh Mansouri, M.D. (see Authors page)

Revised: 1 March 2018, last major update October 2012

Copyright: (c) 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: Infectious mononucleosis[TI] spleen[TI]

Cite this page: Mansouri, J. Infectious mononucleosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/spleeninfectiousmono.html. Accessed March 24th, 2018.
Definition / general
  • May cause spontaneous splenic rupture and death, often 10 - 21 days after disease onset
  • Rupture may be due to increased intrasplenic pressure due to congestion and weakening of splenic capsule from infiltration by immunoblasts
Case reports
Clinical images

Images hosted on other servers:

Grossly enlarged with haematoma

Microscopic (histologic) description
  • Expansion of red pulp with immunoblastic proliferation
  • Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells, infiltrate subintima of intratrabecular veins, occasionally exhibit hemophagocytosis
Positive stains
  • Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
Differential diagnosis