Infectious / inflammatory disorders
Reviewer: Jaleh Mansouri, M.D. (see Reviewers page)
Revised: 11 April 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- May cause spontaneous splenic rupture and death, often 10-21 days after disease onset
- Rupture may be due to increased intrasplenic pressure due to congestion and weakening of splenic capsule from infiltration by immunoblasts
Grossly enlarged with haematoma|
- Expansion of red pulp with immunoblastic proliferation
- Immunoblasts may have strikingly atypical morphology, resemble Reed-Sternberg cells, infiltrate subintima of intratrabecular veins, occasionally exhibit hemophagocytosis
- Immunoblasts are positive for B and T cell markers, EBV by in situ hybridization, variable CD30
End of Spleen > Infectious / inflammatory disorders > Infectious mononucleosis
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other