Anus & perianal area
Other nonneoplastic
Inflammatory cloacogenic polyp

Topic Completed: 1 November 2014

Minor changes: 16 November 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Inflammatory cloacogenic polyp

Elliot Weisenberg, M.D.
Page views in 2020: 7,049
Page views in 2021 to date: 2,618
Cite this page: Weisenberg E. Inflammatory cloacogenic polyp. website. Accessed April 19th, 2021.
Definition / general
  • Middle aged patients with rectal bleeding
  • Single or multiple polyps in anal canal, resemble hemorrhoids
  • Associated with solitary rectal ulcer syndrome or mucosal prolapse; may be due to prolapse with ischemic damage and subsequent repair
  • Patients may also have HPV related disorders
  • Excision
Gross description
  • Sessile, 1 - 2 cm
Microscopic (histologic) description
  • Tubulovillous with elongated, irregular crypts extending into submucosa (resembles colitis cystica profunda)
  • Squamous, colorectal or transitional epithelium, eroded at surface or covered with exudate (Am J Surg Pathol 1981;5:761)
  • May be hyperplastic or regenerative
  • Thickened muscularis mucosa with irregular strands penetrating lamina propria
  • No dysplastic changes, no desmoplasia, no invasion
Microscopic (histologic) images

Contributed by Dr. Yvonne Bury, University Hospital of North Durham (UK)

Various images

Images hosted on other servers:

Low power

Left: H&E, right: PCNA

Differential diagnosis
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