CD Markers

Topic Completed: 1 August 2013

Minor changes: 1 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: CD7[title]

Nat Pernick, M.D.
Page views in 2020: 2,818
Page views in 2021 to date: 929
Cite this page: Pernick N. CD7. website. Accessed April 19th, 2021.
Definition / general
  • T cell cell surface protein that plays important role in T cell-B cell interaction in early lymphoid development
  • Member of immunoglobulin superfamily at 17q25.2-25.3
  • Membrane expression early during T cell development, before TCR rearrangement; persists until terminal stages of T cell development (OMIM #186820)
  • Has costimulatory activity for T cells (Immunol Res 2001;24:31)
  • Binds galectin-1 and is essential for galectin-1-mediated T-cell death; loss of CD7 expression and altered cellular glycosylation may contribute to apoptosis resistance in mycosis fungoides (Mod Pathol 2003;16:543)
Clinical features
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Normal tonsil

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Anaplastic large cell lymphoma is CD7+

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Angioimmunoblastic T cell lymphoma is CD7+

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Cutaneous T cell lymphoma

Positive staining - normal
  • Thymocytes, mature T cells (85%), NK cells (majority, Blood 2009;114:4823)
  • Also monocytes, pluripotent hematopoietic progenitor cells, early myeloid cells, pre-B cells
Positive staining - disease
Negative staining
  • Mature B cells, basophils, granulocytes
  • B cell ALL, mycosis fungoides, adult T cell leukemia / lymphoma (Histopathology 2009;54:214)
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