Other tumors

Blue nevus

Topic Completed: 1 May 2007

Minor changes: 16 November 2020

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Blue nevus cervix

Branko Perunovic, D.M.
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Cite this page: Perunovic B. Blue nevus. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixbluenevus.html. Accessed December 3rd, 2021.
Definition / general
  • Present in up to 2% of cervices; may be more common in Japanese women, particularly if step sections are obtained (Acta Pathol Jpn 1991;41:751)
  • 20% are multiple
  • Usually an incidental finding
Case reports
Gross description
  • Blue / black, flat up to 3 cm
  • Usually ill defined in lower endocervix
Microscopic (histologic) description
  • Elongated, wavy dendritic cells in clusters or individually, below endocervical epithelium
  • Cytoplasm has brown melanin
  • Stromal macrophages
Microscopic (histologic) images

AFIP images

Pigment containing nevus cells in cervical stroma

Positive stains
Negative stains
Electron microscopy description
Differential diagnosis
  • Hemosiderin: coarse granules are refractile and iron+, Fontana-Masson negative; pigment is in macrophages, not spindle cells
  • Melanoma: junctional change, stromal infiltration by malignant cells
  • Melanosis: basal epithelium only, not in stroma
Additional references
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