Premalignant / preinvasive lesions - cytology

Atypical glandular cells (cyto)

Topic Completed: 6 March 2006

Minor changes: 27 August 2021

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PubMed search: cervix Atypical glandular cells (AGC)

Marilin Rosa, M.D.
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Cite this page: Rosa M. Atypical glandular cells (cyto). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixcytologyagc.html. Accessed December 3rd, 2021.
Definition / general
This category is subdivided as follows:

  • Endocervical cells, (NOS or specify in comments)
  • Endometrial cells, (NOS or specify in comments)
  • Glandular cells, (NOS or specify in comments)

  • Endocervical cells, favor neoplastic
  • Glandular cells, favor neoplastic
  • Colposcopy with endocervical sampling is recommended for all subcategories of AGC and AIS (adenocarcinoma in situ)
  • Endometrial sampling is recommended in conjunction with colposcopy and endocervical sampling in women 35 years and older with all subcategories of AGC and AIS, and for women under 35 with clinical risk of endometrial pathology (J Low Genit Tract Dis 2007;11:201)
  • The use of HPV DNA testing or repeat cervical cytology alone is unacceptable for the initial management of all subcategories of AGC and AIS
Cytology description
  • Morphological changes of glandular cells which are too pronounced for inflammatory or reactive origin but insufficient to diagnose adenocarcinoma
  • More likely to be neoplastic if decreased cytoplasm, irregular nuclear membranes, nuclear hyperchromasia and nucleoli present (Cytopathology 2005;16:295)
Cytology images

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