Colon (tumor & nontumor)
Mesenchymal tumors

Topic Completed: 1 November 2017

Minor changes: 31 July 2020

Copyright: 2019, Inc.

PubMed Search: Ganglioneuroma colon

Raul S. Gonzalez, M.D.
Page views in 2019: 3,308
Page views in 2020 to date: 2,162
Cite this page: Gonzalez R. Ganglioneuroma. website. Accessed August 3rd, 2020.
Definition / general
  • Benign mesenchymal polyp in the colon
  • Unrelated to lesion of the same name in the adrenal gland
Essential features
  • Uncommon colonic mesenchymal polyp with prominent ganglion cells
  • Associated with Cowden syndrome, especially if multiple polyps
  • Colorectum is most common site in gastrointestinal tract
Clinical features
  • Typically found during screening colonoscopy
Case reports
  • Polypectomy generally curative
Clinical images

Images hosted on other servers:


Gross description
  • Usually small (a few millimeters) but can rarely grow to 2 - 3 cm
Microscopic (histologic) description
  • Expansion of the lamina propria by bland spindled mesenchymal cells (Schwann cells), lacking atypia or mitotic figures
  • Ganglion cells present within the expanded region; may be rare or abundant
Microscopic (histologic) images

Contributed by Raul S. Gonzalez, M.D.

Case of the Week #305

Contributed by Christopher Hartley, M.D.


Positive stains
Differential diagnosis
Board review style question #1
A 60 year old patient undergoes colonoscopy and is found to have a solitary ganglioneuroma. What should be the next step in working up this patient?

A. Colectomy for possible ganglioneuromatosis
B. Follow-up colonoscopy in 1 year
C. Genetic screening for Cowden syndrome
D. Imaging to search for ganglioneuromas at other sites
E. No further workup needed
Board review answer #1
E. No further workup needed

Reference: Colon tumor - Ganglioneuroma of colon

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