Uvea (iris, choroid and ciliary body), limbus and sclera

Lisch nodule

Topic Completed: 1 October 2014

Minor changes: 1 December 2020

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PubMed Search: Lisch nodules [title] iris

Nat Pernick, M.D.
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Cite this page: Pernick N. Lisch nodule. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyeuvealisch.html. Accessed December 6th, 2021.
Definition / general
  • Pigmented iris hamartomas
  • Associated with neurofibromatosis type 1, also familial angiolipomatosis, a benign condition with no malignant potential (Arch Pathol Lab Med 1999;123:946)
Clinical images

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Lisch nodules

Microscopic (histologic) description
  • Dome shaped papules on anterior surface of iris consisting of aggregates of ovoid to round cells
Positive stains
Differential diagnosis
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