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Kidney nontumor / medical renal

Infection

Malakoplakia

Author: Nikhil Sangle, M.D.

Last author update: 27 March 2015

Last staff update: 18 February 2020

Copyright: 2002-2024, PathologyOutlines.com, Inc.

PubMed Search: Malakoplakia [title] kidney

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Table of Contents

Cite this page: Sangle N. Malakoplakia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/kidneymalakoplakia.html. Accessed April 26th, 2024.

Definition / general

Also spelled malacoplakia
Foamy macrophages with PAS+ granular cytoplasm and Michaelis-Gutmann bodies (may be due to deposition of amorphous salts, Am J Surg Pathol 1984;8:151)
Associated with transplants
May be due to defective macrophage function that blocks lysosomal degradation of engulfed bacteria, filling up cytoplasm with undigested debris

Case reports

65 year old woman with malakoplakia of kidney extending to descending colon (Korean J Fam Med 2011;32:367)

Gross description

Soft, yellow mucosal plaques

Gross images

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Yellowish rubbery solid mass

Microscopic (histologic) description

Foamy macrophages with PAS+ granular cytoplasm due to phagosomes stuffed with bacterial debris and Michaelis-Gutmann bodies (laminated mineralized concretions)
May have rare Michaelis-Gutmann bodies, late fibrous stage (Am J Surg Pathol 1989;13:225)

Microscopic (histologic) images

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