Tumor-like lesions

Fibromatosis and massive edema

Last author update: 1 June 2012
Last staff update: 14 July 2023

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PubMed Search: (Massive edema [title]) ovary

Shahid Islam, M.D., Ph.D.
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Cite this page: Islam S. Fibromatosis and massive edema. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarymassiveedema.html. Accessed November 28th, 2023.
Definition / general
  • Tumor-like enlargement of ovary due to edema fluid
  • First described in 1969 (Obstet Gynecol 1969;34:564)
  • Patients present with pain, abdominal mass, menstrual irregularities, virilization, precocious puberty, Meigs syndrome (with ascites and pleural effusion, eMedicine: Meigs Syndrome)
  • May be due to partial torsion of mesovarium leading to interference of venous / lymphatic drainage
  • Usually young women
  • Right sided involvement is more common
Gross description
  • Marked ovarian enlargement, watery cut surface, no necrosis
Microscopic (histologic) description
  • Marked edema of stroma surrounding follicles and clusters of luteinized cells
  • Stroma around vessels and in superficial cortical zone is normal
  • Variable stromal luteinization
Microscopic (histologic) images

Contributed by Dr. Josehp Christopher Castillo

AFIP images

Clusters of lutein cells lie in the edematous stroma

Images hosted on other servers:

Loose stroma with occasional inflammatory cells

Differential diagnosis
  • Fibroma: circumscribed, tumor cells replace ovarian architecture
  • Krukenberg tumor: usually bilateral, signet ring cells present
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