Cite this page: Lanjewar S, Gupta R. Hydatidiform mole. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentahydatgeneral.html. Accessed December 6th, 2021.
- Risk factors: history of prior mole, primigravid state, southeast Asian / African / Latin American origin, extremes of reproductive age and Vitamin A precursor deficiency
- Hydatidiform mole is an abnormal placenta characterized by enlarged, edematous and vesicular chorionic villi accompanied by villous trophoblastic hyperplasia
- Frequency of hydatidiform moles is higher in Asia and Middle East (100 - 1000/100,000 pregnancies) compared to North America and Europe (100 per 100,000 pregnancies) (Lancet Oncol 2003;4:670)
- Hydatidiform mole is subdivided into complete and partial hydatidiform mole based on morphologic, cytogenetic and clinicopathological features
- All molar pregnancies have the potential for persistent GTD (Lancet Oncol 2003;4:670)
- Complete moles outnumber partial moles in frequency (Am J Surg Pathol 2008;32:445, Am J Obstet Gynecol 2007;196:172.e1) and carry a higher risk of gestational trophoblastic disease
- Surgical curettage is the preferred mode of treatment