Soft tissue

Adipose tissue tumors

Liposarcoma

Atypical spindle cell / pleomorphic lipomatous tumor (pending)



Minor changes: 26 December 2021

Copyright: 2019, PathologyOutlines.com, Inc.

PubMed Search: Atypical spindle cell pleomorphic lipomatous tumor

Nat Pernick, M.D.
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Table of Contents
Definition / general
Cite this page: Pernick N. Atypical spindle cell / pleomorphic lipomatous tumor (pending). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissueaslt.html. Accessed January 19th, 2022.
Definition / general
  • Frequently subcutaneous and contains CD34 positive spindle cells in short fascicles set in a fibrous or fibromyxoid stroma
  • Histologic similarity to neural neoplasms with whorls or a storiforming growth pattern
  • Can have areas of traditional lipoma-like morphology
  • Do not contain MDM2 gene amplifications and instead have been reported to harbor RB1 gene deletions and loss of RB1 IHC staining (Mod Pathol 2010;23:729, Am J Surg Pathol 2017;41:234)
    • Favored diagnosis is atypical spindle cell lipomatous tumor
    • Locally recurrent potential

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