Soft tissue
Vascular
Nonneoplastic
Papillary endothelial hyperplasia
Author: Vijay Shankar, M.D.
Topic Completed: 1 November 2012
Minor changes: 7 December 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed search: Papillary endothelial hyperplasia [title]
Table of Contents
Definition / general | Terminology | Sites | Clinical features | Case reports | Clinical images | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Shankar V. Papillary endothelial hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuemasson.html. Accessed April 18th, 2021.
Definition / general
- Reactive, not neoplastic, representing exuberant organization and recanalization of thrombus
- In normal vessels but also varices, hemorrhoids, pyogenic granulomas, hematomas, angiosarcomas
Terminology
- Also known as Masson's tumor
Sites
- Dermis and subcutis of head and neck, lip, tongue, buccal mucosa
- Also seen in heart, larynx and hypopharynx
Clinical features
- Pure type: within a dilated vascular space
- Mixed type: with preexisting vascular disorder or in a hematoma
- Extravascular form: rare and occurs in extravascular organizing hematoma
- Usually presents as a red blue nodule in skin
Case reports
- 35 year old man with lesion of the paranasal sinus (Arch Pathol Lab Med 2000;124:1224)
- 39 year old man presented with progressive swelling over his midline scalp (Case of the Week #450)
- 39 year old man with painless enlargement of parotid gland (Indian J Pathol Microbiol 2011;54:226)
- 50 year old woman with small bowel lesion (Case Rep Gastroenterol 2010;4:124)
- 70 year old woman with mouth lesion (Case Rep Dermatol 2010;2:22)
Clinical images
Contributed by Mark R. Wick, M.D.
Images hosted on other servers:
Oral mucosa
Gross description
- Small, firm, reddish blue superficial masses in skin
Gross images
Case #450, contributed by K.V. Vinu Balraam, M.D.
Images hosted on other servers:
Small bowel
Microscopic (histologic) description
- Intravascular lesion only, with papillary formations with hyaline or fibrous stalks, anastomosing vascular channels, plump endothelial cells; residual organizing thrombi
- No necrosis, no atypia, no atypical mitotic figures
Microscopic (histologic) images
Case #450, contributed by K.V. Vinu Balraam, M.D.
CD31
CD34
Ki67 / MIB1
Contributed by Mark R. Wick, M.D.
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Images hosted on other servers:
Parotid gland lesion
Oral mucosa
Small bowel
Positive stains
- Factor VIII, alpha smooth muscle actin and CD34 in cells lining the papillae
- Occasionally podoplanin and CD105 (J Oral Sci 2011;53:475)
Differential diagnosis
