Oral cavity & oropharynx
Other nonneoplastic
Pyogenic granuloma

Topic Completed: 1 November 2013

Minor changes: 30 December 2020

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PubMed Search: Pyogenic granuloma oral cavity[mh]

Nat Pernick, M.D.
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Cite this page: Pernick N Pyogenic granuloma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/oralcavitypyogenicgranuloma.html. Accessed June 20th, 2021.
Definition / general
  • Also called lobular capillary hemangioma, pregnancy tumor
  • Most common tumor of gingiva
  • Affects gingiva (usually maxilla) of children, young adults and pregnant women; associated with gingivitis
  • Form of capillary hemangioma that regresses after pregnancy or undergoes fibrous maturation to resemble a fibroma; may be reactive (Am J Surg Pathol 1980;4:470)
  • Excision
Gross description
  • Elevated, dark red lesion, variable ulceration
Microscopic (histologic) description
  • Pedunculated lesion composed of granulation type tissue separated by bands of connective tissue
  • Covering epithelium almost meets at base of lesion; has lobular arrangement of capillaries at base
  • Lobules consist of discrete clusters of endothelial cells with indistinct to prominent lumina
  • Superficial lesion may have secondary changes including stromal edema, capillary dilation, inflammation and granulation tissue reaction
Differential diagnosis
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