Skin nonmelanocytic tumor

Neural tumors


Last author update: 1 November 2012
Last staff update: 9 November 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Neurothekeoma [title] soft tissue

Vijay Shankar, M.D.
Page views in 2022: 15,724
Page views in 2023 to date: 18,776
Cite this page: Shankar V. Neurothekeoma. website. Accessed November 28th, 2023.
Definition / general
  • Superficial tumor, first described in 1980
  • Originally, derivation thought to be from nerve sheath; now thought to derive from fibroblasts with ability to differentiate into myofibroblasts and to recruit histiocytes (Am J Surg Pathol 2007;31:1103)
  • Usually head, upper extremities or shoulder girdle
Clinical features
  • Solitary, superficial, slow growing mass up to 2 cm
  • 60% women, mean age 17 years (range 2 - 85 years), 80% are < age 30 at initial diagnosis
Case reports
  • Excision, may recur
Clinical images

Images hosted on other servers:

Thumb nodule

Lower back

Lower eyelid

Microscopic (histologic) description
  • Cellular, myxoid or mixed subtypes
  • Involves dermis or subcutis
  • Multinodular mass with myxoid matrix and peripheral fibrosis
  • Whorled or focally fascicular patterns of spindled and epithelioid mononuclear cells with abundant cytoplasm, indistinct cell borders
  • Margins usually positive; usually occasional multinucleated giant cells
  • Variable nuclear atypia
  • Median 4 MF / 25 HPF, may have 10+ MF / 25 HPF, may be atypical
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.


Cellular type

Cellular type, skin

Images hosted on other servers:

Left thumb nodule of 5 month old boy

Lower eyelid of elderly man

Positive stains
Negative stains
Differential diagnosis
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