Stomach
Other nonneoplastic
Proton pump inhibitors


Topic Completed: 1 August 2012

Minor changes: 1 September 2020

Copyright: 2003-2021, PathologyOutlines.com, Inc.

PubMed Search: proton pump inhibitors[title]

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Proton pump inhibitors. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stomachPPI.html. Accessed May 15th, 2021.
Definition / general
  • Includes omeprazole, lansoprazole, dexlansoprazole, esomeprazole, rabeprazole
  • Used to treat gastroesophageal reflux disease (GERD)
  • Patients may develop G cell and enterochromaffin cell-like hyperplasia, secondary to drug induced achlorhydria
  • Long-term therapy associated with fundic gland polyps (sessile, multiple, < 1.0 cm) in 17% after 3 months, in 35% after 5 months treatment
  • Polyps regress when treatment stops (Hum Pathol 2000;31:684)
Microscopic (histologic) description
  • Glandular luminal dilatation with swelling and bulging of the superficial cytoplasm of parietal cells (so-called parietal cell protrusion)
  • Glands lined by cells with serrated rather than a smooth border
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