Other nonneoplastic


Topic Completed: 1 August 2012

Minor changes: 1 September 2020

Copyright: 2003-2022,, Inc.

PubMed Search: gastric iron overdose

Elliot Weisenberg, M.D.
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Cite this page: Weisenberg E. Iron. website. Accessed January 22nd, 2022.
Definition / general
  • Iron overdose may cause severe gastrointestinal necrosis and stricture
  • Therapeutic iron causes brown crystalline iron material in superficial gastric biopsies, often mixed with fibrinoinflammatory exudate
  • Usually (83%) associated with erosive or ulcerative mucosal injury, although this may also be due to other disorders (Am J Surg Pathol 1999;23:1241)
Positive stains
  • Prussian blue, Perl's iron
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