Fibroepithelial tumors
Tubular adenoma

Topic Completed: 1 April 2010

Minor changes: 26 August 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Tubular adenoma [title] breast

Hind Warzecha, M.D.
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Cite this page: Warzecha H. Tubular adenoma . website. Accessed November 23rd, 2020.
Definition / general
  • Benign nodules formed by the compact proliferation of tubular structures with 2 cell layers
  • Tubular fibroadenoma: both components are conspicuous and are at least 10% of the lesion
Case reports
  • Excision, does not recur
Gross description
  • Solitary, well circumscribed, tan yellow, soft to firm mass
Microscopic (histologic) description
  • Closely packed uniform small tubules lined by single layer of epithelial cells and attenuated myoepithelium; sparse stroma
  • May have lymphocytic infiltrate, no atypia
Microscopic (histologic) images

Contributed by Jijgee Munkhdelger, M.D., Ph.D. and Andrey Bychkov, M.D., Ph.D.
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Low power

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Mimicking invasion

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Myoepithelial layer on CD10

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Breast tubular adenoma immunoprofile

AFIP images

Ducts of uniform size

Tubular adenoma
pattern above,
pattern below

Images hosted on other servers:

Various images

Circumscribed tumor with packed acini

p63 staining

Myosin staining

Cytology description
  • Three dimensional cohesive balls of ductal cells and tubular structures in highly cellular smears
  • Myoepithelial cells are present with sheets of ductal cells and as bipolar naked nuclei
  • May have staghorn pattern of ductal cells
  • No / scanty stroma (Cytopathology 1998;9:301)
Positive stains
Differential diagnosis
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