CD Markers

Topic Completed: 1 July 2013

Minor changes: 8 August 2019

Revised: 13 December 2018, last major update July 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: CD25[TI] review[ptyp]

Nat Pernick, M.D.
Page views in 2019: 4,178
Page views in 2020 to date: 3,377
Cite this page: Pernick N. CD25. website. Accessed September 29th, 2020.
Definition / general
  • Marker for hairy cell leukemia and systemic mastocytosis
  • Also called IL-2 receptor alpha chain, IL2RA and TAC antigen (OMIM 147730)
Diagrams / tables

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Development of CD4+ CD25+ T cells

Clinical features
Uses by pathologists
Microscopic (histologic) images

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HTLV1+ adult T cell leukemia / lymphoma

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Hodgkin lymphoma

Positive staining - normal
  • Activated B and T cells, macrophages, osteoblasts; some thymocytes, some myeloid precursors and some oligodendocytes; basophils have dim staining by flow cytometry (Arch Pathol Lab Med 2008;132:813)
Positive staining - disease
Negative staining
Flow cytometry images

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Hairy cell leukemia variant is CD103+ but CD25-

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