CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 22 December 2015, last major update July 2013

Copyright: (c) 2002-2015,, Inc.

Cite this page: CD25. website. Accessed July 21st, 2018.
Definition / general
  • Marker for hairy cell leukemia and systemic mastocytosis
  • Also called IL-2 receptor alpha chain, IL2RA and TAC antigen (OMIM 147730)

Development of CD4+ CD25+ T cells

Clinical features
Uses by pathologists
Microscopic (histologic) images

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HTLV1+ adult T cell leukemia / lymphoma



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Hodgkin lymphoma

Images hosted on

Cutaneous T cell lymphoma

Hairy cell leukemia

Positive staining - normal
  • Activated B and T cells, macrophages, osteoblasts; some thymocytes, some myeloid precursors and some oligodendocytes; basophils have dim staining by flow cytometry (Arch Pathol Lab Med 2008;132:813)
Positive staining - disease
Negative staining
Flow cytometry Images

Hairy cell leukemia variant is CD103+ but CD25-