Stains & CD markers
CD270-279
Copyright: 2019-2024, PathologyOutlines.com, Inc.
CD270-279
Author: Nat Pernick, M.D.
Last author update: 13 November 2019
Last staff update: 24 April 2024 (update in progress)
Copyright: 2019-2024, PathologyOutlines.com, Inc.
Cite this page: Pernick N. CD270-279. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cdmarkerscd270to279.html. Accessed May 8th, 2024.
CD270
- Also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), Herpesvirus entry mediator (HVEM) (GeneCards)
- Ligand to B and T lymphocyte attenuator (BTLA, Diagn Pathol 2012;7:142)
- Acts as receptor for Herpes simplex virus (Virology 2014;448:185)
- Recurrent mutations associated with pediatric follicular lymphoma (Haematologica 2013;98:1237)
- Acquired mutations associated with worse prognosis in follicular lymphoma (Cancer Res 2010;70:9166)
- No uses for pathologists at this time
- Positive staining: T cells (constitutive or induced)
CD272 / BTLA
- B and T lymphocyte attenuator (BTLA) is a recently discovered inhibitory receptor belonging to the CD28 family
- Expressed by most lymphocytes; shares structural and functional similarities with CTLA4 / cytotoxic T lymphocyte antigen 4 / CD152 and PD1 / programmed death 1 (PD1), although only 9-13% amino acid identify (Arch Immunol Ther Exp (Warsz) 2015;63:73)
- Interacts with CD270 / herpesvirus entry mediator (HVEM), a TNFR superfamily member found on T, B, NK, DC and other cells
- Has a negative regulatory role in diverse immune responses
- Expression on αβ T cells is likely associated with protective immune memory against Mycobacteria tuberculosis infection in patients with active pulmonary tuberculosis (Am J Transl Res 2014;6:494)
- May contribute to immune escape (Blood 2013;122:922, Cancer Res 2012;72:887)
- In mice, BTLA antibodies prevented graft versus host disease without global immunosuppression (J Exp Med 2010;207:2551)
- No uses for pathologists at this time
CD273
CD274
- See PDL1 22C3
CD278
- Also called ICOS
- Enhances basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that mediate cell-cell interaction and effective help for antibody secretion by B-cells
- Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens
- Plays a critical role in CD40-mediated class switching of immunoglobin isotypes
- A type I membrane protein
- Defects cause ICOS deficiency (OMIM 607594), a form of common variable immunodeficiency characterized by recurrent bacterial infections of the respiratory and digestive tracts, but without splenomegaly, autoimmune disease, sarcoid-like granulomas, overt T cell immunodeficiency
- Present in: activated T cells, tonsillar T cells, fetal and newborn thymic medulla
- Reference: Swiss-Prot entry
CD279
- See PD1
