Stains & CD markers

Last author update: 13 November 2019
Last staff update: 18 September 2023 (update in progress)

Copyright: 2019-2023,, Inc.

Nat Pernick, M.D.
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Table of Contents
CD270 | CD272 / BTLA | CD273 | CD274 | CD278 | CD279
Cite this page: Pernick N. CD270-279. website. Accessed November 29th, 2023.
  • Also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), Herpesvirus entry mediator (HVEM) (GeneCards)
  • Ligand to B and T lymphocyte attenuator (BTLA, Diagn Pathol 2012;7:142)
  • Acts as receptor for Herpes simplex virus (Virology 2014;448:185)
  • Recurrent mutations associated with pediatric follicular lymphoma (Haematologica 2013;98:1237)
  • Acquired mutations associated with worse prognosis in follicular lymphoma (Cancer Res 2010;70:9166)
  • No uses for pathologists at this time
  • Positive staining: T cells (constitutive or induced)
CD272 / BTLA
  • Programmed cell death ligand 2; also called B7DC
  • Involved in the costimulatory signal, essential for T lymphocyte proliferation and interferon gamma production
  • Found in the plasma membrane
  • Also called ICOS
  • Enhances basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that mediate cell-cell interaction and effective help for antibody secretion by B-cells
  • Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens
  • Plays a critical role in CD40-mediated class switching of immunoglobin isotypes
  • A type I membrane protein
  • Defects cause ICOS deficiency (OMIM 607594), a form of common variable immunodeficiency characterized by recurrent bacterial infections of the respiratory and digestive tracts, but without splenomegaly, autoimmune disease, sarcoid-like granulomas, overt T cell immunodeficiency
  • Present in: activated T cells, tonsillar T cells, fetal and newborn thymic medulla
  • Reference: Swiss-Prot entry
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